Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions

Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions

TonEBP/NFAT5 is a major regulator of the urinary concentrating process and is essential for the osmoadaptation of renal medullary cells. Focal adhesion kinase (FAK) is a mechanosensitive non-receptor protein tyrosine kinase expressed abundantly in the renal medulla. Since osmotic stress causes cell...

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Bibliographic Details
Main Authors: Neuhofer, Wolfgang, Küper, Christoph, Lichtnekert, Julia, Holzapfel, Konstantin, Rupanagudi, Khader V., Fraek, Maria-Luisa, Bartels, Helmut, Beck, Franz-Xaver
Format: Online
Language:English
Published: Frontiers Media S.A. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983490/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983490/

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