Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue

The genetic regulation of the human epigenome is not fully appreciated. Here we describe the effects of genetic variants on the DNA methylome in human lung based on methylation-quantitative trait loci (meQTL) analyses. We report 34,304 cis- and 585 trans-meQTLs, a genetic-epigenetic interaction of s...

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Main Authors: Shi, Jianxin, Marconett, Crystal N., Duan, Jubao, Hyland, Paula L., Li, Peng, Wang, Zhaoming, Wheeler, William, Zhou, Beiyun, Campan, Mihaela, Lee, Diane S., Huang, Jing, Zhou, Weiyin, Triche, Tim, Amundadottir, Laufey, Warner, Andrew, Hutchinson, Amy, Chen, Po-Han, Chung, Brian S.I., Pesatori, Angela C., Consonni, Dario, Bertazzi, Pier Alberto, Bergen, Andrew W., Freedman, Mathew, Siegmund, Kimberly D., Berman, Benjamin P., Borok, Zea, Chatterjee, Nilanjan, Tucker, Margaret A., Caporaso, Neil E., Chanock, Stephen J., Laird-Offringa, Ite A., Landi, Maria Teresa
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982882/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982882/

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