Electrostimulation to reduce synaptic scaling driven progression of Alzheimer's disease

Cell death and synapse dysfunction are two likely causes of cognitive decline in AD. As cells die and synapses lose their drive, remaining cells suffer an initial decrease in activity. Neuronal homeostatic synaptic scaling then provides a feedback mechanism to restore activity. This homeostatic mech...

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Bibliographic Details
Main Authors: Rowan, Mark S., Neymotin, Samuel A., Lytton, William W.
Format: Online
Language:English
Published: Frontiers Media S.A. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982056/