Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia
An 82-year-old man known case of chronic lymphocytic leukemia (CLL) presented with fever and weakness. He had never received any treatment for his CLL in the past. On admission he was found to be in mild respiratory distress with bilateral crackles and had markedly elevated white blood count (WBC) (...
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PAGEPress Publications
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981247/ |
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pubmed-39812472014-04-24 Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia Hosseinnezhad, Alireza Seguel, Joseph M. Villanueva, Andrew G. Case Report An 82-year-old man known case of chronic lymphocytic leukemia (CLL) presented with fever and weakness. He had never received any treatment for his CLL in the past. On admission he was found to be in mild respiratory distress with bilateral crackles and had markedly elevated white blood count (WBC) (137 K/uL with 93% lymphocytes). His respiratory status deteriorated necessitating non-invasive ventilatory support. Chest computed tomography (CT) scan revealed bilateral diffuse ground glass opacities, so broad spectrum antibiotic therapy was initiated. Despite that, he remained febrile and cultures were all negative. Chest x-rays showed progressive worsening of diffuse alveolar opacities. Bronchoalveolar lavage (BAL) was negative for infectious etiologies, however flow cytometry of the fluid was consistent with CLL. Chemotherapy with chlorambucil was started. Although most of the pulmonary infiltrates in CLL patients are due to infectious causes, leukemic cells infiltration should be considered as well in CLL patients with respiratory symptoms who do not respond appropriately to standard antimicrobial regimen. PAGEPress Publications 2011-05-31 /pmc/articles/PMC3981247/ /pubmed/24765302 http://dx.doi.org/10.4081/cp.2011.e41 Text en ©Copyright A. Hosseinnezhad et al., 2011 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Hosseinnezhad, Alireza Seguel, Joseph M. Villanueva, Andrew G. |
| spellingShingle |
Hosseinnezhad, Alireza Seguel, Joseph M. Villanueva, Andrew G. Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia |
| author_facet |
Hosseinnezhad, Alireza Seguel, Joseph M. Villanueva, Andrew G. |
| author_sort |
Hosseinnezhad, Alireza |
| title |
Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia |
| title_short |
Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia |
| title_full |
Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia |
| title_fullStr |
Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia |
| title_full_unstemmed |
Diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia |
| title_sort |
diffuse pulmonary infiltrates in an old man with chronic lymphocytic leukemia |
| description |
An 82-year-old man known case of chronic lymphocytic leukemia (CLL) presented with fever and weakness. He had never received any treatment for his CLL in the past. On admission he was found to be in mild respiratory distress with bilateral crackles and had markedly elevated white blood count (WBC) (137 K/uL with 93% lymphocytes). His respiratory status deteriorated necessitating non-invasive ventilatory support. Chest computed tomography (CT) scan revealed bilateral diffuse ground glass opacities, so broad spectrum antibiotic therapy was initiated. Despite that, he remained febrile and cultures were all negative. Chest x-rays showed progressive worsening of diffuse alveolar opacities. Bronchoalveolar lavage (BAL) was negative for infectious etiologies, however flow cytometry of the fluid was consistent with CLL. Chemotherapy with chlorambucil was started. Although most of the pulmonary infiltrates in CLL patients are due to infectious causes, leukemic cells infiltration should be considered as well in CLL patients with respiratory symptoms who do not respond appropriately to standard antimicrobial regimen. |
| publisher |
PAGEPress Publications |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981247/ |
| _version_ |
1612076219182874624 |