Not so WEE: Targeting G2/M to kill mesothelioma cells
It has been known for many years that manipulation of cell cycle checkpoint function represents one approach by which the toxicity of chemotherapy and of ionizing radiation can be increased in tumor cells.1-3 In particular, abrogation of the G2/M checkpoint has been shown to enhance the lethality of...
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| Format: | Online |
| Language: | English |
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Landes Bioscience
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979810/ |
| Summary: | It has been known for many years that manipulation of cell cycle checkpoint function represents one approach by which the toxicity of chemotherapy and of ionizing radiation can be increased in tumor cells.1-3 In particular, abrogation of the G2/M checkpoint has been shown to enhance the lethality of a wide range of toxic stresses.1-3 Inhibition of the G2/M checkpoint after chemotherapy/irradiation would result in tumor cells entering mitosis with damaged DNA, which would in turn result in loss of clonogenic survival (i.e., a lethal mitosis). |
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