Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malaria-infected mice at a single oral dose of only 8 mg/k...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Molecular Diversity Preservation International
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978545/ |