Dynamic Cross Talk Model of the Epithelial Innate Immune Response to Double-Stranded RNA Stimulation: Coordinated Dynamics Emerging from Cell-Level Noise

Dynamic Cross Talk Model of the Epithelial Innate Immune Response to Double-Stranded RNA Stimulation: Coordinated Dynamics Emerging from Cell-Level Noise

We present an integrated dynamical cross-talk model of the epithelial innate immune reponse (IIR) incorporating RIG-I and TLR3 as the two major pattern recognition receptors (PRR) converging on the RelA and IRF3 transcriptional effectors. bioPN simulations reproduce biologically relevant gene-and pr...

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Bibliographic Details
Main Authors: Bertolusso, Roberto, Tian, Bing, Zhao, Yingxin, Vergara, Leoncio, Sabree, Aqeeb, Iwanaszko, Marta, Lipniacki, Tomasz, Brasier, Allan R., Kimmel, Marek
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977818/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977818/

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