Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many physiological and pathophysiological cell responses. p38...

Full description

Bibliographic Details
Main Authors:	Yang, Yanyan, Kim, Seung Cheol, Yu, Tao, Yi, Young-Su, Rhee, Man Hee, Sung, Gi-Ho, Yoo, Byong Chul, Cho, Jae Youl
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977509/

id	pubmed-3977509
recordtype	oai_dc
spelling	pubmed-39775092014-04-27 Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses Yang, Yanyan Kim, Seung Cheol Yu, Tao Yi, Young-Su Rhee, Man Hee Sung, Gi-Ho Yoo, Byong Chul Cho, Jae Youl Review Article Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many physiological and pathophysiological cell responses. p38 MAPKs are key MAPKs involved in the production of inflammatory mediators, including tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2). p38 MAPK signaling plays an essential role in regulating cellular processes, especially inflammation. In this paper, we summarize the characteristics of p38 signaling in macrophage-mediated inflammation. In addition, we discuss the potential of using inhibitors targeting p38 expression in macrophages to treat inflammatory diseases. Hindawi Publishing Corporation 2014 2014-03-20 /pmc/articles/PMC3977509/ /pubmed/24771982 http://dx.doi.org/10.1155/2014/352371 Text en Copyright © 2014 Yanyan Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yang, Yanyan Kim, Seung Cheol Yu, Tao Yi, Young-Su Rhee, Man Hee Sung, Gi-Ho Yoo, Byong Chul Cho, Jae Youl
spellingShingle	Yang, Yanyan Kim, Seung Cheol Yu, Tao Yi, Young-Su Rhee, Man Hee Sung, Gi-Ho Yoo, Byong Chul Cho, Jae Youl Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
author_facet	Yang, Yanyan Kim, Seung Cheol Yu, Tao Yi, Young-Su Rhee, Man Hee Sung, Gi-Ho Yoo, Byong Chul Cho, Jae Youl
author_sort	Yang, Yanyan
title	Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
title_short	Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
title_full	Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
title_fullStr	Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
title_full_unstemmed	Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
title_sort	functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses
description	Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many physiological and pathophysiological cell responses. p38 MAPKs are key MAPKs involved in the production of inflammatory mediators, including tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2). p38 MAPK signaling plays an essential role in regulating cellular processes, especially inflammation. In this paper, we summarize the characteristics of p38 signaling in macrophage-mediated inflammation. In addition, we discuss the potential of using inhibitors targeting p38 expression in macrophages to treat inflammatory diseases.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977509/
_version_	1612074807633903616

Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Similar Items