EIAV-Based Retinal Gene Therapy in the shaker1 Mouse Model for Usher Syndrome Type 1B: Development of UshStat

EIAV-Based Retinal Gene Therapy in the shaker1 Mouse Model for Usher Syndrome Type 1B: Development of UshStat

Usher syndrome type 1B is a combined deaf-blindness condition caused by mutations in the MYO7A gene. Loss of functional myosin VIIa in the retinal pigment epithelia (RPE) and/or photoreceptors leads to blindness. We evaluated the impact of subretinally delivered UshStat, a recombinant EIAV-based len...

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Bibliographic Details
Main Authors: Zallocchi, Marisa, Binley, Katie, Lad, Yatish, Ellis, Scott, Widdowson, Peter, Iqball, Sharifah, Scripps, Vicky, Kelleher, Michelle, Loader, Julie, Miskin, James, Peng, You-Wei, Wang, Wei-Min, Cheung, Linda, Delimont, Duane, Mitrophanous, Kyriacos A., Cosgrove, Dominic
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976400/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976400/

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