A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor

A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor

Class B G protein-coupled receptors (GPCRs) are important regulators of endocrine physiology, and peptide-based therapeutics targeting some of these receptors have proven effective at treating disorders such as hypercalcemia, osteoporosis, and type 2 diabetes mellitus (T2DM). As next generation effo...

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Bibliographic Details
Main Authors: Jun, Lucy S., Showalter, Aaron D., Ali, Nosher, Dai, Feihan, Ma, Wenzhen, Coskun, Tamer, Ficorilli, James V., Wheeler, Michael B., Michael, M. Dodson, Sloop, Kyle W.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973576/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973576/

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