Clonal selection and therapy resistance in acute leukaemias: mathematical modelling explains different proliferation patterns at diagnosis and relapse
Recent experimental evidence suggests that acute myeloid leukaemias may originate from multiple clones of malignant cells. Nevertheless, it is not known how the observed clones may differ with respect to cell properties, such as proliferation and self-renewal. There are scarcely any data on how thes...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Royal Society
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973374/ |