The structure and substrate specificity of human Cdk12/Cyclin K

The structure and substrate specificity of human Cdk12/Cyclin K

Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription. Here we determine the crystal structure of Cdk12/CycK and analyse its requirements for substrate recognition. Active Cdk12/CycK is arranged in an open conformation...

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Bibliographic Details
Main Authors: Bösken, Christian A., Farnung, Lucas, Hintermair, Corinna, Merzel Schachter, Miriam, Vogel-Bachmayr, Karin, Blazek, Dalibor, Anand, Kanchan, Fisher, Robert P., Eick, Dirk, Geyer, Matthias
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973122/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973122/

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