MicroRNAs-Role in Lung Cancer

MicroRNAs-Role in Lung Cancer

Regulation of gene expression is essential for normal physiological functions; thus deregulation of gene expression is common in disease conditions. One level of regulation of gene expression is performed by noncoding RNAs, among which microRNAs (miRNA) are the best studied. Abnormal expression of t...

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Main Authors: Guz, Małgorzata, Rivero-Müller, Adolfo, Okoń, Estera, Stenzel-Bembenek, Agnieszka, Polberg, Krzysztof, Słomka, Maria, Stepulak, Andrzej
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972902/
id pubmed-3972902
recordtype oai_dc
spelling pubmed-39729022014-04-17 MicroRNAs-Role in Lung Cancer Guz, Małgorzata Rivero-Müller, Adolfo Okoń, Estera Stenzel-Bembenek, Agnieszka Polberg, Krzysztof Słomka, Maria Stepulak, Andrzej Review Article Regulation of gene expression is essential for normal physiological functions; thus deregulation of gene expression is common in disease conditions. One level of regulation of gene expression is performed by noncoding RNAs, among which microRNAs (miRNA) are the best studied. Abnormal expression of these molecular players can lead to pathogenic processes such as heart disease, immune system abnormalities, and carcinogenesis, to name but a few. Of a length of 18–25 nucleotides miRNAs are involved in binding partial complementary sequences within the 3′-UTR (3′-untranslated region) of the target mRNAs. Depending on the type of neoplastic transformation, miRNAs can act both as oncogenes (oncomirs) or as tumor suppressors. Because of the great importance of miRNAs, most researches focus on either their role as biomarkers or their potential as therapeutic targets. Herein, we present the review of microRNA biology, function, and tumorigenic potential with emphasis on their role in lung cancer. Hindawi Publishing Corporation 2014 2014-03-13 /pmc/articles/PMC3972902/ /pubmed/24744457 http://dx.doi.org/10.1155/2014/218169 Text en Copyright © 2014 Małgorzata Guz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Guz, Małgorzata
Rivero-Müller, Adolfo
Okoń, Estera
Stenzel-Bembenek, Agnieszka
Polberg, Krzysztof
Słomka, Maria
Stepulak, Andrzej
spellingShingle Guz, Małgorzata
Rivero-Müller, Adolfo
Okoń, Estera
Stenzel-Bembenek, Agnieszka
Polberg, Krzysztof
Słomka, Maria
Stepulak, Andrzej
MicroRNAs-Role in Lung Cancer
author_facet Guz, Małgorzata
Rivero-Müller, Adolfo
Okoń, Estera
Stenzel-Bembenek, Agnieszka
Polberg, Krzysztof
Słomka, Maria
Stepulak, Andrzej
author_sort Guz, Małgorzata
title MicroRNAs-Role in Lung Cancer
title_short MicroRNAs-Role in Lung Cancer
title_full MicroRNAs-Role in Lung Cancer
title_fullStr MicroRNAs-Role in Lung Cancer
title_full_unstemmed MicroRNAs-Role in Lung Cancer
title_sort micrornas-role in lung cancer
description Regulation of gene expression is essential for normal physiological functions; thus deregulation of gene expression is common in disease conditions. One level of regulation of gene expression is performed by noncoding RNAs, among which microRNAs (miRNA) are the best studied. Abnormal expression of these molecular players can lead to pathogenic processes such as heart disease, immune system abnormalities, and carcinogenesis, to name but a few. Of a length of 18–25 nucleotides miRNAs are involved in binding partial complementary sequences within the 3′-UTR (3′-untranslated region) of the target mRNAs. Depending on the type of neoplastic transformation, miRNAs can act both as oncogenes (oncomirs) or as tumor suppressors. Because of the great importance of miRNAs, most researches focus on either their role as biomarkers or their potential as therapeutic targets. Herein, we present the review of microRNA biology, function, and tumorigenic potential with emphasis on their role in lung cancer.
publisher Hindawi Publishing Corporation
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972902/
_version_ 1612073227009392640

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