Polμ Deficiency Increases Resistance to Oxidative Damage and Delays Liver Aging

Polμ Deficiency Increases Resistance to Oxidative Damage and Delays Liver Aging

Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ−/−) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ−/− mice have increased learning...

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Bibliographic Details
Main Authors: Escudero, Beatriz, Lucas, Daniel, Albo, Carmen, Dhup, Suveera, Bacher, Jeff W., Sánchez-Muñoz, Aránzazu, Fernández, Margarita, Rivera-Torres, José, Carmona, Rosa M., Fuster, Encarnación, Carreiro, Candelas, Bernad, Raquel, González, Manuel A., Andrés, Vicente, Blanco, Luis, Roche, Enrique, Fabregat, Isabel, Samper, Enrique, Bernad, Antonio
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972199/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972199/

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