VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation

VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation

Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism of such anticancer effects remains incompletely understood. In this study,...

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Bibliographic Details
Main Authors: Zhang, Yan-Ting, Xu, Li-Hui, Lu, Qun, Liu, Kun-Peng, Liu, Pei-Yan, Ji, Fang, Liu, Xiao-Ming, Ouyang, Dong-Yun, He, Xian-Hui
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972149/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972149/

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