Adult Neurogenesis and Glial Oncogenesis: When the Process Fails

Malignant brain tumors, including glioblastoma multiforme (GBM), are known for their high degree of invasiveness, aggressiveness, and lethality. These tumors are made up of heterogeneous cell populations and only a small part of these cells (known as cancer stem cells) is responsible for the initiat...

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Main Authors:	Batista, Chary Marquez, Mariano, Eric Domingos, Barbosa, Breno José Alencar Pires, Morgalla, Matthias, Marie, Suely Kazue Nagahashi, Teixeira, Manoel Jacobsen, Lepski, Guilherme
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971505/

id	pubmed-3971505
recordtype	oai_dc
spelling	pubmed-39715052014-04-15 Adult Neurogenesis and Glial Oncogenesis: When the Process Fails Batista, Chary Marquez Mariano, Eric Domingos Barbosa, Breno José Alencar Pires Morgalla, Matthias Marie, Suely Kazue Nagahashi Teixeira, Manoel Jacobsen Lepski, Guilherme Review Article Malignant brain tumors, including glioblastoma multiforme (GBM), are known for their high degree of invasiveness, aggressiveness, and lethality. These tumors are made up of heterogeneous cell populations and only a small part of these cells (known as cancer stem cells) is responsible for the initiation and recurrence of the tumor. The biology of cancer stem cells and their role in brain tumor growth and therapeutic resistance has been extensively investigated. Recent work suggests that glial tumors arise from neural stem cells that undergo a defective process of differentiation. The understanding of this process might permit the development of novel treatment strategies targeting cancer stem cells. In the present review, we address the mechanisms underlying glial tumor formation, paying special attention to cancer stem cells and the role of the microenvironment in preserving them and promoting tumor growth. Recent advancements in cancer stem cell biology, especially regarding tumor initiation and resistance to chemo- or radiotherapy, have led to the development of novel treatment strategies that focus on the niche of the stem cells that make up the tumor. Encouraging results from preclinical studies predict that these findings will be translated into the clinical field in the near future. Hindawi Publishing Corporation 2014 2014-03-11 /pmc/articles/PMC3971505/ /pubmed/24738058 http://dx.doi.org/10.1155/2014/438639 Text en Copyright © 2014 Chary Marquez Batista et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Batista, Chary Marquez Mariano, Eric Domingos Barbosa, Breno José Alencar Pires Morgalla, Matthias Marie, Suely Kazue Nagahashi Teixeira, Manoel Jacobsen Lepski, Guilherme
spellingShingle	Batista, Chary Marquez Mariano, Eric Domingos Barbosa, Breno José Alencar Pires Morgalla, Matthias Marie, Suely Kazue Nagahashi Teixeira, Manoel Jacobsen Lepski, Guilherme Adult Neurogenesis and Glial Oncogenesis: When the Process Fails
author_facet	Batista, Chary Marquez Mariano, Eric Domingos Barbosa, Breno José Alencar Pires Morgalla, Matthias Marie, Suely Kazue Nagahashi Teixeira, Manoel Jacobsen Lepski, Guilherme
author_sort	Batista, Chary Marquez
title	Adult Neurogenesis and Glial Oncogenesis: When the Process Fails
title_short	Adult Neurogenesis and Glial Oncogenesis: When the Process Fails
title_full	Adult Neurogenesis and Glial Oncogenesis: When the Process Fails
title_fullStr	Adult Neurogenesis and Glial Oncogenesis: When the Process Fails
title_full_unstemmed	Adult Neurogenesis and Glial Oncogenesis: When the Process Fails
title_sort	adult neurogenesis and glial oncogenesis: when the process fails
description	Malignant brain tumors, including glioblastoma multiforme (GBM), are known for their high degree of invasiveness, aggressiveness, and lethality. These tumors are made up of heterogeneous cell populations and only a small part of these cells (known as cancer stem cells) is responsible for the initiation and recurrence of the tumor. The biology of cancer stem cells and their role in brain tumor growth and therapeutic resistance has been extensively investigated. Recent work suggests that glial tumors arise from neural stem cells that undergo a defective process of differentiation. The understanding of this process might permit the development of novel treatment strategies targeting cancer stem cells. In the present review, we address the mechanisms underlying glial tumor formation, paying special attention to cancer stem cells and the role of the microenvironment in preserving them and promoting tumor growth. Recent advancements in cancer stem cell biology, especially regarding tumor initiation and resistance to chemo- or radiotherapy, have led to the development of novel treatment strategies that focus on the niche of the stem cells that make up the tumor. Encouraging results from preclinical studies predict that these findings will be translated into the clinical field in the near future.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971505/
_version_	1612072861218897920

Adult Neurogenesis and Glial Oncogenesis: When the Process Fails

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