Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni

Members of the genus Campylobacter are frequently responsible for human enteric disease, often through consumption of contaminated poultry products. Bacteriophages are viruses that have the potential to control pathogenic bacteria, but understanding their complex life cycles is key to their successf...

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Main Authors:	Siringan, Patcharin, Connerton, Phillippa L., Cummings, Nicola J., Connerton, Ian F.
Format:	Online
Language:	English
Published:	The Royal Society 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971406/

id	pubmed-3971406
recordtype	oai_dc
spelling	pubmed-39714062014-04-16 Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni Siringan, Patcharin Connerton, Phillippa L. Cummings, Nicola J. Connerton, Ian F. Research Members of the genus Campylobacter are frequently responsible for human enteric disease, often through consumption of contaminated poultry products. Bacteriophages are viruses that have the potential to control pathogenic bacteria, but understanding their complex life cycles is key to their successful exploitation. Treatment of Campylobacter jejuni biofilms with bacteriophages led to the discovery that phages had established a relationship with their hosts typical of the carrier state life cycle (CSLC), where bacteria and bacteriophages remain associated in equilibrium. Significant phenotypic changes include improved aerotolerance under nutrient-limited conditions that would confer an advantage to survive in extra-intestinal environments, but a lack in motility eliminated their ability to colonize chickens. Under these circumstances, phages can remain associated with a compatible host and continue to produce free virions to prospect for new hosts. Moreover, we demonstrate that CSLC host bacteria can act as expendable vehicles for the delivery of bacteriophages to new host bacteria within pre-colonized chickens. The CSLC represents an important phase in the ecology of Campylobacter bacteriophage. The Royal Society 2014-03-26 /pmc/articles/PMC3971406/ /pubmed/24671947 http://dx.doi.org/10.1098/rsob.130200 Text en http://creativecommons.org/licenses/by/3.0/ © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Siringan, Patcharin Connerton, Phillippa L. Cummings, Nicola J. Connerton, Ian F.
spellingShingle	Siringan, Patcharin Connerton, Phillippa L. Cummings, Nicola J. Connerton, Ian F. Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni
author_facet	Siringan, Patcharin Connerton, Phillippa L. Cummings, Nicola J. Connerton, Ian F.
author_sort	Siringan, Patcharin
title	Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni
title_short	Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni
title_full	Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni
title_fullStr	Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni
title_full_unstemmed	Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni
title_sort	alternative bacteriophage life cycles: the carrier state of campylobacter jejuni
description	Members of the genus Campylobacter are frequently responsible for human enteric disease, often through consumption of contaminated poultry products. Bacteriophages are viruses that have the potential to control pathogenic bacteria, but understanding their complex life cycles is key to their successful exploitation. Treatment of Campylobacter jejuni biofilms with bacteriophages led to the discovery that phages had established a relationship with their hosts typical of the carrier state life cycle (CSLC), where bacteria and bacteriophages remain associated in equilibrium. Significant phenotypic changes include improved aerotolerance under nutrient-limited conditions that would confer an advantage to survive in extra-intestinal environments, but a lack in motility eliminated their ability to colonize chickens. Under these circumstances, phages can remain associated with a compatible host and continue to produce free virions to prospect for new hosts. Moreover, we demonstrate that CSLC host bacteria can act as expendable vehicles for the delivery of bacteriophages to new host bacteria within pre-colonized chickens. The CSLC represents an important phase in the ecology of Campylobacter bacteriophage.
publisher	The Royal Society
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971406/
_version_	1612072827107672064

Alternative bacteriophage life cycles: the carrier state of Campylobacter jejuni

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