Recombinant antigens based on toxins A and B of Clostridium difficile that evoke a potent toxin-neutralising immune response☆
•Definition of Clostridium difficile toxin-derived antigens for soluble expression in E. coli.•Demonstration of their potent neutralising immune response against key epidemic strain toxins.•TcdA and TcdB were different with respect to the domains that evoke a neutralising immune response.•TcdB centr...
| Main Authors: | , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969267/ |