The Role of Coronary Collaterals in Chronic Total Occlusions
A chronic total occlusion (CTO) describes a completely occluded coronary artery. This type of lesion is found in about 18% of all significant lesions in patients with coronary artery disease. A system of collateral connections are observed in almost all of these lesions, which have the capacity to p...
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| Format: | Online |
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Bentham Science Publishers
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968594/ |
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pubmed-3968594 |
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pubmed-39685942015-02-01 The Role of Coronary Collaterals in Chronic Total Occlusions Werner, Gerald S. Article A chronic total occlusion (CTO) describes a completely occluded coronary artery. This type of lesion is found in about 18% of all significant lesions in patients with coronary artery disease. A system of collateral connections are observed in almost all of these lesions, which have the capacity to prevent myocardial necrosis and may even uphold metabolic supply to the territory distal to an occlusion to maintain full contractile capacity. During exercise these collaterals are limited in their functional reserve, and more than 90% of patients with a well collateralized occlusion will experience ischemia. in the absence of ideal animal models that mimic the human collateral circulation, we need to rely on studies in man. The knowledge of collateral physiology in man has increased considerably over the past two decades with the advent of intracoronary sensors of coronary pressure and flow velocity. A number of basic physiologic questions have been answered by these studies. The blood supply through coronary arteries depends on a complex array of in general serial resistance systems, with an additional array of multiple parallel resistances on the collateral level. Bentham Science Publishers 2014-02 2014-02 /pmc/articles/PMC3968594/ /pubmed/24611646 http://dx.doi.org/10.2174/1573403X10666140311123814 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Werner, Gerald S. |
| spellingShingle |
Werner, Gerald S. The Role of Coronary Collaterals in Chronic Total Occlusions |
| author_facet |
Werner, Gerald S. |
| author_sort |
Werner, Gerald S. |
| title |
The Role of Coronary Collaterals in Chronic Total Occlusions |
| title_short |
The Role of Coronary Collaterals in Chronic Total Occlusions |
| title_full |
The Role of Coronary Collaterals in Chronic Total Occlusions |
| title_fullStr |
The Role of Coronary Collaterals in Chronic Total Occlusions |
| title_full_unstemmed |
The Role of Coronary Collaterals in Chronic Total Occlusions |
| title_sort |
role of coronary collaterals in chronic total occlusions |
| description |
A chronic total occlusion (CTO) describes a completely occluded coronary artery. This type of lesion is found
in about 18% of all significant lesions in patients with coronary artery disease. A system of collateral connections are observed
in almost all of these lesions, which have the capacity to prevent myocardial necrosis and may even uphold metabolic
supply to the territory distal to an occlusion to maintain full contractile capacity. During exercise these collaterals
are limited in their functional reserve, and more than 90% of patients with a well collateralized occlusion will experience
ischemia. in the absence of ideal animal models that mimic the human collateral circulation, we need to rely on studies in
man. The knowledge of collateral physiology in man has increased considerably over the past two decades with the advent
of intracoronary sensors of coronary pressure and flow velocity. A number of basic physiologic questions have been answered
by these studies. The blood supply through coronary arteries depends on a complex array of in general serial resistance
systems, with an additional array of multiple parallel resistances on the collateral level. |
| publisher |
Bentham Science Publishers |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968594/ |
| _version_ |
1612072099428433920 |