A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy
Photoacoustic microscopy (PAM) does not rely on contrast agent to image the optical absorption contrast in biological tissue. It is uniquely suited for measuring several tissue physiological parameters, such as hemoglobin oxygen saturation, that would otherwise remain challenging. Researchers are de...
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| Format: | Online |
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Nature Publishing Group
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968454/ |
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pubmed-39684542014-03-28 A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy Li, Hao Dong, Biqin Zhang, Zhen Zhang, Hao F. Sun, Cheng Article Photoacoustic microscopy (PAM) does not rely on contrast agent to image the optical absorption contrast in biological tissue. It is uniquely suited for measuring several tissue physiological parameters, such as hemoglobin oxygen saturation, that would otherwise remain challenging. Researchers are designing new clinical diagnostic tools and multimodal microscopic systems around PAM to fully unleash its potential. However, the sizeable and opaque piezoelectric ultrasonic detectors commonly used in PAM impose a serious constraint. Our solution is a coverslip-style optically transparent ultrasound detector based on a polymeric optical micro-ring resonator (MRR) with a total thickness of 250 μm. It enables highly-sensitive ultrasound detection over a wide receiving angle with a bandwidth of 140 MHz, which corresponds to a photoacoustic saturation limit of 287 cm−1, at an estimated noise-equivalent pressure (NEP) of 6.8 Pa. We also established a theoretical framework for designing and optimizing the MRR for PAM. Nature Publishing Group 2014-03-28 /pmc/articles/PMC3968454/ /pubmed/24675547 http://dx.doi.org/10.1038/srep04496 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Li, Hao Dong, Biqin Zhang, Zhen Zhang, Hao F. Sun, Cheng |
| spellingShingle |
Li, Hao Dong, Biqin Zhang, Zhen Zhang, Hao F. Sun, Cheng A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy |
| author_facet |
Li, Hao Dong, Biqin Zhang, Zhen Zhang, Hao F. Sun, Cheng |
| author_sort |
Li, Hao |
| title |
A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy |
| title_short |
A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy |
| title_full |
A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy |
| title_fullStr |
A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy |
| title_full_unstemmed |
A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy |
| title_sort |
transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy |
| description |
Photoacoustic microscopy (PAM) does not rely on contrast agent to image the optical absorption contrast in biological tissue. It is uniquely suited for measuring several tissue physiological parameters, such as hemoglobin oxygen saturation, that would otherwise remain challenging. Researchers are designing new clinical diagnostic tools and multimodal microscopic systems around PAM to fully unleash its potential. However, the sizeable and opaque piezoelectric ultrasonic detectors commonly used in PAM impose a serious constraint. Our solution is a coverslip-style optically transparent ultrasound detector based on a polymeric optical micro-ring resonator (MRR) with a total thickness of 250 μm. It enables highly-sensitive ultrasound detection over a wide receiving angle with a bandwidth of 140 MHz, which corresponds to a photoacoustic saturation limit of 287 cm−1, at an estimated noise-equivalent pressure (NEP) of 6.8 Pa. We also established a theoretical framework for designing and optimizing the MRR for PAM. |
| publisher |
Nature Publishing Group |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968454/ |
| _version_ |
1612072066086862848 |