Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing

Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing

Monoclonal antibodies targeting the Epidermal Growth Factor Receptor (EGFR), such as cetuximab and panitumumab, have evolved to important therapeutic options in metastatic colorectal cancer (CRC). However, almost all patients with clinical response to anti-EGFR therapies show disease progression wit...

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Bibliographic Details
Main Authors: Mohan, Sumitra, Heitzer, Ellen, Ulz, Peter, Lafer, Ingrid, Lax, Sigurd, Auer, Martina, Pichler, Martin, Gerger, Armin, Eisner, Florian, Hoefler, Gerald, Bauernhofer, Thomas, Geigl, Jochen B., Speicher, Michael R.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967949/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967949/

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