Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience
Follicular thyroid carcinoma classically accounts for 10–32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was perfor...
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Hindawi Publishing Corporation
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967639/ |
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pubmed-39676392014-04-16 Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience De Crea, Carmela Raffaelli, Marco Sessa, Luca Ronti, Simona Fadda, Guido Bellantone, Chiara Lombardi, Celestino Pio Clinical Study Follicular thyroid carcinoma classically accounts for 10–32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was performed. The medical records of all patients who underwent thyroidectomy from October 1998 to April 2012 for thyroid malignancies were reviewed. Those who had a histological diagnosis of follicular carcinoma were included. Among 5203 patients, 130 (2.5%) were included. Distant metastases at presentation were observed in four patients. Sixty-six patients had a minimally invasive follicular carcinoma and 64 a widely invasive follicular carcinoma. In 63 patients an oxyphilic variant was registered. Minimally/widely invasive ratio was 41/26 for usual follicular carcinoma and 25/38 for oxyphilic variant (P < 0.05). Patients with widely invasive tumors had larger tumors (P < 0.001) and more frequently oxyphilic variant (P < 0.05) than those with minimally invasive tumours. No significant difference was found between widely invasive and minimally invasive tumors and between usual follicular carcinoma and oxyphilic variant regarding the recurrence rate (P = NS). The incidence of follicular thyroid carcinoma is much lower than classically retained. Aggressive treatment, including total thyroidectomy and radioiodine ablation, should be proposed to all patients. Hindawi Publishing Corporation 2014-03-04 /pmc/articles/PMC3967639/ /pubmed/24741369 http://dx.doi.org/10.1155/2014/952095 Text en Copyright © 2014 Carmela De Crea et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
De Crea, Carmela Raffaelli, Marco Sessa, Luca Ronti, Simona Fadda, Guido Bellantone, Chiara Lombardi, Celestino Pio |
| spellingShingle |
De Crea, Carmela Raffaelli, Marco Sessa, Luca Ronti, Simona Fadda, Guido Bellantone, Chiara Lombardi, Celestino Pio Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience |
| author_facet |
De Crea, Carmela Raffaelli, Marco Sessa, Luca Ronti, Simona Fadda, Guido Bellantone, Chiara Lombardi, Celestino Pio |
| author_sort |
De Crea, Carmela |
| title |
Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience |
| title_short |
Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience |
| title_full |
Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience |
| title_fullStr |
Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience |
| title_full_unstemmed |
Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience |
| title_sort |
actual incidence and clinical behaviour of follicular thyroid carcinoma: an institutional experience |
| description |
Follicular thyroid carcinoma classically accounts for 10–32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was performed.
The medical records of all patients who underwent thyroidectomy from October 1998 to April 2012 for thyroid malignancies were reviewed. Those who had a histological diagnosis of follicular carcinoma were included. Among 5203 patients, 130 (2.5%) were included. Distant metastases at presentation were observed in four patients. Sixty-six patients had a minimally invasive follicular carcinoma and 64 a widely invasive follicular carcinoma. In 63 patients an oxyphilic variant was registered. Minimally/widely invasive ratio was 41/26 for usual follicular carcinoma and 25/38 for oxyphilic variant (P < 0.05). Patients with widely invasive tumors had larger tumors (P < 0.001) and more frequently oxyphilic variant (P < 0.05) than those with minimally invasive tumours. No significant difference was found between widely invasive and minimally invasive tumors and between usual follicular carcinoma and oxyphilic variant regarding the recurrence rate (P = NS). The incidence of follicular thyroid carcinoma is much lower than classically retained. Aggressive treatment, including total thyroidectomy and radioiodine ablation, should be proposed to all patients. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967639/ |
| _version_ |
1612071779055960064 |