Store-operated Ca2+ entry in muscle physiology and diseases

Ca2+ release from intracellular stores and influx from extracellular reservoir regulate a wide range of physiological functions including muscle contraction and rhythmic heartbeat. One of the most ubiquitous pathways involved in controlled Ca2+ influx into cells is store-operated Ca2+ entry (SOCE),...

Full description

Bibliographic Details
Main Authors:	Pan, Zui, Brotto, Marco, Ma, Jianjie
Format:	Online
Language:	English
Published:	Korean Society for Biochemistry and Molecular Biology 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967412/

id	pubmed-3967412
recordtype	oai_dc
spelling	pubmed-39674122014-08-01 Store-operated Ca2+ entry in muscle physiology and diseases Pan, Zui Brotto, Marco Ma, Jianjie Review Article Ca2+ release from intracellular stores and influx from extracellular reservoir regulate a wide range of physiological functions including muscle contraction and rhythmic heartbeat. One of the most ubiquitous pathways involved in controlled Ca2+ influx into cells is store-operated Ca2+ entry (SOCE), which is activated by the reduction of Ca2+ concentration in the lumen of endoplasmic or sarcoplasmic reticulum (ER/SR). Although SOCE is pronounced in non-excitable cells, accumulating evidences highlight its presence and important roles in skeletal muscle and heart. Recent discovery of STIM proteins as ER/SR Ca2+ sensors and Orai proteins as Ca2+ channel pore forming unit expedited the mechanistic understanding of this pathway. This review focuses on current advances of SOCE components, regulation and physiologic and pathophysiologic roles in muscles. The specific property and the dysfunction of this pathway in muscle diseases, and new directions for future research in this rapidly growing field are discussed. [BMB Reports 2014; 47(2): 69-79] Korean Society for Biochemistry and Molecular Biology 2014-02 /pmc/articles/PMC3967412/ /pubmed/24411466 http://dx.doi.org/10.5483/BMBRep.2014.47.2.015 Text en Copyright © 2014, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pan, Zui Brotto, Marco Ma, Jianjie
spellingShingle	Pan, Zui Brotto, Marco Ma, Jianjie Store-operated Ca2+ entry in muscle physiology and diseases
author_facet	Pan, Zui Brotto, Marco Ma, Jianjie
author_sort	Pan, Zui
title	Store-operated Ca2+ entry in muscle physiology and diseases
title_short	Store-operated Ca2+ entry in muscle physiology and diseases
title_full	Store-operated Ca2+ entry in muscle physiology and diseases
title_fullStr	Store-operated Ca2+ entry in muscle physiology and diseases
title_full_unstemmed	Store-operated Ca2+ entry in muscle physiology and diseases
title_sort	store-operated ca2+ entry in muscle physiology and diseases
description	Ca2+ release from intracellular stores and influx from extracellular reservoir regulate a wide range of physiological functions including muscle contraction and rhythmic heartbeat. One of the most ubiquitous pathways involved in controlled Ca2+ influx into cells is store-operated Ca2+ entry (SOCE), which is activated by the reduction of Ca2+ concentration in the lumen of endoplasmic or sarcoplasmic reticulum (ER/SR). Although SOCE is pronounced in non-excitable cells, accumulating evidences highlight its presence and important roles in skeletal muscle and heart. Recent discovery of STIM proteins as ER/SR Ca2+ sensors and Orai proteins as Ca2+ channel pore forming unit expedited the mechanistic understanding of this pathway. This review focuses on current advances of SOCE components, regulation and physiologic and pathophysiologic roles in muscles. The specific property and the dysfunction of this pathway in muscle diseases, and new directions for future research in this rapidly growing field are discussed. [BMB Reports 2014; 47(2): 69-79]
publisher	Korean Society for Biochemistry and Molecular Biology
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967412/
_version_	1612071722170712064

Store-operated Ca2+ entry in muscle physiology and diseases

Similar Items