A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis

A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis

Male spermatogenesis is an essential and complex process necessary to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms underlying spermatogenesis, detailed global profiling of all the key meiotic...

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Main Authors: Fallahi, Mohammad, Getun, Irina V., Wu, Zhen K., Bois, Philippe R.J.
Format: Online
Language:English
Published: MDPI 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966219/
id pubmed-3966219
recordtype oai_dc
spelling pubmed-39662192014-03-26 A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis Fallahi, Mohammad Getun, Irina V. Wu, Zhen K. Bois, Philippe R.J. Article Male spermatogenesis is an essential and complex process necessary to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms underlying spermatogenesis, detailed global profiling of all the key meiotic stages is required to fully define these processes. Here, by isolating highly enriched mouse meiotic cell populations, we have generated a comprehensive gene expression atlas of mammalian meiosis. Our data define unique signatures for the specific stages of meiosis, including global chromosome X inactivation and reactivation. The data also reveal profound switches in global gene expression at the initiation of pachynema that are reminiscent of the commitment to meiosis observed in budding yeast. Overall, this meiotic atlas provides an exhaustive blueprint and resource for mammalian gametogenesis and meiosis. MDPI 2010-12-13 /pmc/articles/PMC3966219/ /pubmed/24710097 http://dx.doi.org/10.3390/genes1030469 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Fallahi, Mohammad
Getun, Irina V.
Wu, Zhen K.
Bois, Philippe R.J.
spellingShingle Fallahi, Mohammad
Getun, Irina V.
Wu, Zhen K.
Bois, Philippe R.J.
A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis
author_facet Fallahi, Mohammad
Getun, Irina V.
Wu, Zhen K.
Bois, Philippe R.J.
author_sort Fallahi, Mohammad
title A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis
title_short A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis
title_full A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis
title_fullStr A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis
title_full_unstemmed A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis
title_sort global expression switch marks pachytene initiation during mouse male meiosis
description Male spermatogenesis is an essential and complex process necessary to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms underlying spermatogenesis, detailed global profiling of all the key meiotic stages is required to fully define these processes. Here, by isolating highly enriched mouse meiotic cell populations, we have generated a comprehensive gene expression atlas of mammalian meiosis. Our data define unique signatures for the specific stages of meiosis, including global chromosome X inactivation and reactivation. The data also reveal profound switches in global gene expression at the initiation of pachynema that are reminiscent of the commitment to meiosis observed in budding yeast. Overall, this meiotic atlas provides an exhaustive blueprint and resource for mammalian gametogenesis and meiosis.
publisher MDPI
publishDate 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966219/
_version_ 1612071366247317504

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