A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp

A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp

Mis-sense mutations in the α-subunit of the G-protein, Gsα, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these mutations is constitutively active Gsα and increased levels of cAMP. The aim of this study was to develop an assay system that would allow the identi...

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Bibliographic Details
Main Authors: Bhattacharyya, Nisan, Hu, Xin, Chen, Catherine Z., Mathews Griner, Lesley A., Zheng, Wei, Inglese, James, Austin, Christopher P., Marugan, Juan J., Southall, Noel, Neumann, Susanne, Northup, John K., Ferrer, Marc, Collins, Michael T.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965391/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965391/

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