Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas

Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas

The present study conducted an immunohistochemical investigation of cyclin D1 and Ki-67 expression in oral squamous cell carcinoma (SCC) to evaluate the correlations between cell differentiation, cell proliferation and metastasis, and the effect of anticancer drug medication and cyclin D1 expression...

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Main Authors: OHNISHI, YUICHI, WATANABE, MASAHIRO, WATO, MASAHIRO, TANAKA, AKIO, KAKUDO, KENJI, NOZAKI, MASAMI
Format: Online
Language:English
Published: D.A. Spandidos 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961451/
id pubmed-3961451
recordtype oai_dc
spelling pubmed-39614512014-06-18 Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas OHNISHI, YUICHI WATANABE, MASAHIRO WATO, MASAHIRO TANAKA, AKIO KAKUDO, KENJI NOZAKI, MASAMI Articles The present study conducted an immunohistochemical investigation of cyclin D1 and Ki-67 expression in oral squamous cell carcinoma (SCC) to evaluate the correlations between cell differentiation, cell proliferation and metastasis, and the effect of anticancer drug medication and cyclin D1 expression. Cyclin D1 and Ki-67 were detected clearly in the nuclei of 35 SCC samples. No correlation between cyclin D1 protein expression and oral SCC differentiation was found. By contrast, the majority of metastatic foci (90%) exhibited strong cyclin D1 expression, whereas weak expression was observed in metastatic foci with pre-operative adjuvant therapy. Additionally, cyclin D1 and Ki-67 were expressed in basal to suprabasal cells of well-differentiated oral SCC, whereas cyclin D1-positive and Ki-67-negative cells were present in the highly-differentiated region, according to a double-immunostaining method. These results indicate that the expression of cyclin D1 protein plays a role in cell differentiation and cell proliferation in well-differentiated oral SCC. D.A. Spandidos 2014-04 2014-02-13 /pmc/articles/PMC3961451/ /pubmed/24944679 http://dx.doi.org/10.3892/ol.2014.1880 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author OHNISHI, YUICHI
WATANABE, MASAHIRO
WATO, MASAHIRO
TANAKA, AKIO
KAKUDO, KENJI
NOZAKI, MASAMI
spellingShingle OHNISHI, YUICHI
WATANABE, MASAHIRO
WATO, MASAHIRO
TANAKA, AKIO
KAKUDO, KENJI
NOZAKI, MASAMI
Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
author_facet OHNISHI, YUICHI
WATANABE, MASAHIRO
WATO, MASAHIRO
TANAKA, AKIO
KAKUDO, KENJI
NOZAKI, MASAMI
author_sort OHNISHI, YUICHI
title Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
title_short Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
title_full Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
title_fullStr Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
title_full_unstemmed Cyclin D1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
title_sort cyclin d1 expression is correlated with cell differentiation and cell proliferation in oral squamous cell carcinomas
description The present study conducted an immunohistochemical investigation of cyclin D1 and Ki-67 expression in oral squamous cell carcinoma (SCC) to evaluate the correlations between cell differentiation, cell proliferation and metastasis, and the effect of anticancer drug medication and cyclin D1 expression. Cyclin D1 and Ki-67 were detected clearly in the nuclei of 35 SCC samples. No correlation between cyclin D1 protein expression and oral SCC differentiation was found. By contrast, the majority of metastatic foci (90%) exhibited strong cyclin D1 expression, whereas weak expression was observed in metastatic foci with pre-operative adjuvant therapy. Additionally, cyclin D1 and Ki-67 were expressed in basal to suprabasal cells of well-differentiated oral SCC, whereas cyclin D1-positive and Ki-67-negative cells were present in the highly-differentiated region, according to a double-immunostaining method. These results indicate that the expression of cyclin D1 protein plays a role in cell differentiation and cell proliferation in well-differentiated oral SCC.
publisher D.A. Spandidos
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961451/
_version_ 1612070032013000704

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