A modified HPLC method improves the simultaneous determination of plasma kynurenine and tryptophan concentrations in patients following maintenance hemodialysis

A modified HPLC method improves the simultaneous determination of plasma kynurenine and tryptophan concentrations in patients following maintenance hemodialysis

The ratio between plasma kynurenine (Kyn) and tryptophan (Trp) serves as a marker of indoleamine 2,3-dioxygenase, a critical immunomodulatory molecule. Simultaneous detection of the two markers may be performed using high-pressure liquid chromatography (HPLC). However, for uremic patients, the conve...

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Bibliographic Details
Main Authors: XIAO, CHENGGEN, CHEN, YUANHAN, LIANG, XINLING, XIE, ZHEN, ZHANG, MIN, LI, RUIZHAO, LI, ZHILIAN, FU, XIA, YU, XIYONG, SHI, WEI
Format: Online
Language:English
Published: D.A. Spandidos 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961120/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961120/

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