Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver
•Emerging studies suggest that ApoE has other functions beyond cholesterol metabolism.•At 32-weeks, insulin signaling was similar in both ApoE3 and ApoE4 knock-in mice.•At 72-weeks, IRS1 and PI3K expression and Akt phosphorylation were reduced in ApoE4 mice.•Aged huApoE4 mice also have lower liver i...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958919/ |