Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration

Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration

Although corticosteroids (CSs) affect gene expression in multiple tissues, the array of genes that are regulated by these catabolic steroids is diverse, highly tissue specific, and depends on their functions in the tissue. Liver has many important functions in performing and regulating diverse metab...

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Main Authors: Nguyen, Tung T, Almon, Richard R, DuBois, Debra C, Sukumaran, Siddharth, Jusko, William J, Androulakis, Ioannis P
Format: Online
Language:English
Published: Libertas Academica 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956809/
id pubmed-3956809
recordtype oai_dc
spelling pubmed-39568092014-03-20 Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration Nguyen, Tung T Almon, Richard R DuBois, Debra C Sukumaran, Siddharth Jusko, William J Androulakis, Ioannis P Methodology Although corticosteroids (CSs) affect gene expression in multiple tissues, the array of genes that are regulated by these catabolic steroids is diverse, highly tissue specific, and depends on their functions in the tissue. Liver has many important functions in performing and regulating diverse metabolic processes. Muscle, in addition to its mechanical role, is critical in maintaining systemic energy homeostasis and accounts for about 80% of insulin-directed glucose disposal. Consequently, a better understanding of CS pharmacogenomic effects in these tissues would provide valuable information regarding the tissue-specificity of transcriptional dynamics, and would provide insights into the underlying molecular mechanisms of action for both beneficial and detrimental effects. Libertas Academica 2014-03-10 /pmc/articles/PMC3956809/ /pubmed/24653645 http://dx.doi.org/10.4137/GRSB.S13134 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Nguyen, Tung T
Almon, Richard R
DuBois, Debra C
Sukumaran, Siddharth
Jusko, William J
Androulakis, Ioannis P
spellingShingle Nguyen, Tung T
Almon, Richard R
DuBois, Debra C
Sukumaran, Siddharth
Jusko, William J
Androulakis, Ioannis P
Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration
author_facet Nguyen, Tung T
Almon, Richard R
DuBois, Debra C
Sukumaran, Siddharth
Jusko, William J
Androulakis, Ioannis P
author_sort Nguyen, Tung T
title Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration
title_short Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration
title_full Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration
title_fullStr Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration
title_full_unstemmed Tissue-Specific Gene Expression and Regulation in Liver and Muscle Following Chronic Corticosteroid Administration
title_sort tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration
description Although corticosteroids (CSs) affect gene expression in multiple tissues, the array of genes that are regulated by these catabolic steroids is diverse, highly tissue specific, and depends on their functions in the tissue. Liver has many important functions in performing and regulating diverse metabolic processes. Muscle, in addition to its mechanical role, is critical in maintaining systemic energy homeostasis and accounts for about 80% of insulin-directed glucose disposal. Consequently, a better understanding of CS pharmacogenomic effects in these tissues would provide valuable information regarding the tissue-specificity of transcriptional dynamics, and would provide insights into the underlying molecular mechanisms of action for both beneficial and detrimental effects.
publisher Libertas Academica
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956809/
_version_ 1612068519173685248

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