R-Loops in Proliferating Cells but Not in the Brain: Implications for AOA2 and Other Autosomal Recessive Ataxias

R-Loops in Proliferating Cells but Not in the Brain: Implications for AOA2 and Other Autosomal Recessive Ataxias

Disruption of the Setx gene, defective in ataxia oculomotor apraxia type 2 (AOA2) leads to the accumulation of DNA/RNA hybrids (R-loops), failure of meiotic recombination and infertility in mice. We report here the presence of R-loops in the testes from other autosomal recessive ataxia mouse models,...

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Bibliographic Details
Main Authors: Yeo, Abrey J., Becherel, Olivier J., Luff, John E., Cullen, Jason K., Wongsurawat, Thidathip, Jenjaroenpoon, Piroon, Kuznetsov, Vladimir A., McKinnon, Peter J., Lavin, Martin F.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956458/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956458/

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