The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability

Human cognitive ability shows consistent, positive associations with fitness components across the life-course. Underlying genetic variation should therefore be depleted by selection, which is not observed. Genetic variation in general cognitive ability (intelligence) could be maintained by a mutati...

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Bibliographic Details
Main Authors: Marioni, Riccardo E., Penke, Lars, Davies, Gail, Huffman, Jennifer E., Hayward, Caroline, Deary, Ian J.
Format: Online
Language:English
Published: The Royal Society 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953855/