Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

Tumor angiogenesis is mainly mediated by vascular endothelial growth factor (VEGF), a pro-angiogenic factor produced by cancer cells and active on the endothelium through the VEGF receptor 2 (VEGFR-2). Here we identify a G-rich sequence within the proximal promoter region of vegfr-2, able to form an...

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Bibliographic Details
Main Authors: Salvati, Erica, Zizza, Pasquale, Rizzo, Angela, Iachettini, Sara, Cingolani, Chiara, D’Angelo, Carmen, Porru, Manuela, Randazzo, Antonio, Pagano, Bruno, Novellino, Ettore, Pisanu, Maria Elena, Stoppacciaro, Antonella, Spinella, Francesca, Bagnato, Anna, Gilson, Eric, Leonetti, Carlo, Biroccio, Annamaria
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950687/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950687/

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