Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo

Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo

Cryptococcosis is an infectious disease of global significance for which new therapies are needed. Repurposing previously developed drugs for new indications can expedite the translation of new therapies from bench to beside. Here, we characterized the anti-cryptococcal activity and antifungal mecha...

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Bibliographic Details
Main Authors: Butts, Arielle, Koselny, Kristy, Chabrier-Roselló, Yeissa, Semighini, Camile P., Brown, Jessica C. S., Wang, Xuying, Annadurai, Sivakumar, DiDone, Louis, Tabroff, Julie, Childers, Wayne E., Abou-Gharbia, Magid, Wellington, Melanie, Cardenas, Maria E., Madhani, Hiten D., Heitman, Joseph, Krysan, Damian J.
Format: Online
Language:English
Published: American Society of Microbiology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950514/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950514/

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