Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat

Increased bodily CO2 concentration alters cellular pH as well as sleep. The proton pump, which plays an important role in the homeostatic regulation of cellular pH, therefore, may modulate sleep. We investigated the effects of the proton pump inhibitor “lansoprazole” on sleep-wakefulness. Male Wista...

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Main Authors:	Qureshi, Munazah Fazal, Jha, Sushil K.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950396/

id	pubmed-3950396
recordtype	oai_dc
spelling	pubmed-39503962014-04-03 Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat Qureshi, Munazah Fazal Jha, Sushil K. Research Article Increased bodily CO2 concentration alters cellular pH as well as sleep. The proton pump, which plays an important role in the homeostatic regulation of cellular pH, therefore, may modulate sleep. We investigated the effects of the proton pump inhibitor “lansoprazole” on sleep-wakefulness. Male Wistar rats were surgically prepared for chronic polysomnographic recordings. Two different doses of lansoprazole (low: 1 mg/kg; high: 10 mg/kg) were injected intraperitoneally in the same animal (n = 7) and sleep-wakefulness was recorded for 6 hrs. The changes in sleep-wakefulness were compared statistically. Percent REM sleep amount in the vehicle and lansoprazole low dose groups was 9.26 ± 1.03 and 9.09 ± 0.54, respectively, which increased significantly in the lansoprazole high dose group by 31.75% (from vehicle) and 34.21% (from low dose). Also, REM sleep episode numbers significantly increased in lansoprazole high dose group. Further, the sodium-hydrogen exchanger blocker “amiloride” (10 mg/kg; i.p.) (n = 5) did not alter sleep-wake architecture. Our results suggest that the proton pump plays an important role in REM sleep modulation and supports our view that REM sleep might act as a sentinel to help maintain normal CO2 level for unperturbed sleep. Hindawi Publishing Corporation 2014 2014-02-19 /pmc/articles/PMC3950396/ /pubmed/24701564 http://dx.doi.org/10.1155/2014/162314 Text en Copyright © 2014 M. F. Qureshi and S. K. Jha. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Qureshi, Munazah Fazal Jha, Sushil K.
spellingShingle	Qureshi, Munazah Fazal Jha, Sushil K. Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat
author_facet	Qureshi, Munazah Fazal Jha, Sushil K.
author_sort	Qureshi, Munazah Fazal
title	Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat
title_short	Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat
title_full	Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat
title_fullStr	Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat
title_full_unstemmed	Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat
title_sort	proton pump inhibition increases rapid eye movement sleep in the rat
description	Increased bodily CO2 concentration alters cellular pH as well as sleep. The proton pump, which plays an important role in the homeostatic regulation of cellular pH, therefore, may modulate sleep. We investigated the effects of the proton pump inhibitor “lansoprazole” on sleep-wakefulness. Male Wistar rats were surgically prepared for chronic polysomnographic recordings. Two different doses of lansoprazole (low: 1 mg/kg; high: 10 mg/kg) were injected intraperitoneally in the same animal (n = 7) and sleep-wakefulness was recorded for 6 hrs. The changes in sleep-wakefulness were compared statistically. Percent REM sleep amount in the vehicle and lansoprazole low dose groups was 9.26 ± 1.03 and 9.09 ± 0.54, respectively, which increased significantly in the lansoprazole high dose group by 31.75% (from vehicle) and 34.21% (from low dose). Also, REM sleep episode numbers significantly increased in lansoprazole high dose group. Further, the sodium-hydrogen exchanger blocker “amiloride” (10 mg/kg; i.p.) (n = 5) did not alter sleep-wake architecture. Our results suggest that the proton pump plays an important role in REM sleep modulation and supports our view that REM sleep might act as a sentinel to help maintain normal CO2 level for unperturbed sleep.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950396/
_version_	1612066553444958208

Proton Pump Inhibition Increases Rapid Eye Movement Sleep in the Rat

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