Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity is Mediated by ERα Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers (DNMT3A, MBD2, and HDAC2) in the Mouse Seminal Vesicle

Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity is Mediated by ERα Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers (DNMT3A, MBD2, and HDAC2) in the Mouse Seminal Vesicle

Background: Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin...

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Bibliographic Details
Main Authors: Li, Yin, Hamilton, Katherine J., Lai, Anne Y., Burns, Katherine A., Li, Leping, Wade, Paul A., Korach, Kenneth S.
Format: Online
Language:English
Published: National Institute of Environmental Health Sciences 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948038/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948038/

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