Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China

Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China

To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published lite...

Full description

Bibliographic Details
Main Authors: Ye, Zhen, Cong, Liming, Ding, Gangqiang, Yu, Min, Zhang, Xinwei, Hu, Ruying, Wu, Jianjun, Fang, Le, Wang, Hao, Zhang, Jie, He, Qingfang, Su, Danting, Zhao, Ming, Wang, Lixin, Gong, Weiwei, Xiao, Yuanyuan, Liang, Mingbin, Pan, Jin
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946449/
id pubmed-3946449
recordtype oai_dc
spelling pubmed-39464492014-03-10 Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China Ye, Zhen Cong, Liming Ding, Gangqiang Yu, Min Zhang, Xinwei Hu, Ruying Wu, Jianjun Fang, Le Wang, Hao Zhang, Jie He, Qingfang Su, Danting Zhao, Ming Wang, Lixin Gong, Weiwei Xiao, Yuanyuan Liang, Mingbin Pan, Jin Research Article To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published literatures. Two-step strategy was used among 17437 subjects sampled from population to screen undiagnosed diabetes. Effectiveness (proportion of cases identified), costs (including medical and non-medical costs), and efficiency (cost per case identified) of these different two-step screening strategies were evaluated. This study found the sensitivities of all the two-step screening strategies with further Oral Glucose Tolerance Test (OGTT) at different Fasting Plasma Glucose (FPG) cut-off points from 5.0 to 7.0 (mmol/L) ranged from 0.66 to 0.91. For the FPG point of 5.0 mmol/L, 91 percent of undiagnosed cases were identified. The total cost of detecting one undiagnosed diabetes case ranged from 547.1 to 1294.5 CNY/case, and the strategy with FPG at cut-off point of 6.1 (mmol/L) resulted in the least cost. Considering both sensitivity and cost of screening diabetes, FPG cut-off point at 5.4 mmol/L was optimized for the two-step strategy. In conclusion, different optimal cut-off points of FPG for two-step strategy in screening of undiagnosed diabetes should be used for different screening purposes. Public Library of Science 2014-03-07 /pmc/articles/PMC3946449/ /pubmed/24609110 http://dx.doi.org/10.1371/journal.pone.0087690 Text en © 2014 Ye et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ye, Zhen
Cong, Liming
Ding, Gangqiang
Yu, Min
Zhang, Xinwei
Hu, Ruying
Wu, Jianjun
Fang, Le
Wang, Hao
Zhang, Jie
He, Qingfang
Su, Danting
Zhao, Ming
Wang, Lixin
Gong, Weiwei
Xiao, Yuanyuan
Liang, Mingbin
Pan, Jin
spellingShingle Ye, Zhen
Cong, Liming
Ding, Gangqiang
Yu, Min
Zhang, Xinwei
Hu, Ruying
Wu, Jianjun
Fang, Le
Wang, Hao
Zhang, Jie
He, Qingfang
Su, Danting
Zhao, Ming
Wang, Lixin
Gong, Weiwei
Xiao, Yuanyuan
Liang, Mingbin
Pan, Jin
Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China
author_facet Ye, Zhen
Cong, Liming
Ding, Gangqiang
Yu, Min
Zhang, Xinwei
Hu, Ruying
Wu, Jianjun
Fang, Le
Wang, Hao
Zhang, Jie
He, Qingfang
Su, Danting
Zhao, Ming
Wang, Lixin
Gong, Weiwei
Xiao, Yuanyuan
Liang, Mingbin
Pan, Jin
author_sort Ye, Zhen
title Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China
title_short Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China
title_full Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China
title_fullStr Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China
title_full_unstemmed Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China
title_sort optimal cut-off points for two-step strategy in screening of undiagnosed diabetes: a population-based study in china
description To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published literatures. Two-step strategy was used among 17437 subjects sampled from population to screen undiagnosed diabetes. Effectiveness (proportion of cases identified), costs (including medical and non-medical costs), and efficiency (cost per case identified) of these different two-step screening strategies were evaluated. This study found the sensitivities of all the two-step screening strategies with further Oral Glucose Tolerance Test (OGTT) at different Fasting Plasma Glucose (FPG) cut-off points from 5.0 to 7.0 (mmol/L) ranged from 0.66 to 0.91. For the FPG point of 5.0 mmol/L, 91 percent of undiagnosed cases were identified. The total cost of detecting one undiagnosed diabetes case ranged from 547.1 to 1294.5 CNY/case, and the strategy with FPG at cut-off point of 6.1 (mmol/L) resulted in the least cost. Considering both sensitivity and cost of screening diabetes, FPG cut-off point at 5.4 mmol/L was optimized for the two-step strategy. In conclusion, different optimal cut-off points of FPG for two-step strategy in screening of undiagnosed diabetes should be used for different screening purposes.
publisher Public Library of Science
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946449/
_version_ 1612065712026681344

Similar Items