Rapid induction of Alternative Lengthening of Telomeres by depletion of the histone chaperone ASF1

Rapid induction of Alternative Lengthening of Telomeres by depletion of the histone chaperone ASF1

The mechanism of activation of the Alternative Lengthening of Telomeres (ALT) pathway of mammalian chromosome end maintenance has remained an unresolved issue. We have discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT in both primary a...

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Bibliographic Details
Main Authors: O’Sullivan, Roderick J., Arnoult, Nausica, Lackner, Daniel H., Oganesian, Liana, Haggblom, Candy, Corpet, Armelle, Almouzni, Genevieve, Karlseder, Jan
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946341/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946341/

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