Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance
Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated Tau (tangles). Here we show that AD animals have high levels of insoluble parkin and decreased parkin-Beclin...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Blackwell Science Inc
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944464/ |