Transactivation of bad by vorinostat-induced acetylated p53 enhances doxorubicin-induced cytotoxicity in cervical cancer cells

Vorinostat (VOR) has been reported to enhance the cytotoxic effects of doxorubicin (DOX) with fewer side effects because of the lower DOX dosage in breast cancer cells. In this study, we investigated the novel mechanism underlying the synergistic cytotoxic effects of VOR and DOX co-treatment in cerv...

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Bibliographic Details
Main Authors: Lee, Sook-Jeong, Hwang, Sung-Ook, Noh, Eun Joo, Kim, Dong-Uk, Nam, Miyoung, Kim, Jong Hyeok, Nam, Joo Hyun, Hoe, Kwang-Lae
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944441/