A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function is largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N), also known as Ubc13, is an E2 ubiquitin-conjugating enzyme that promotes formation of mono...

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Bibliographic Details
Main Authors: Cheng, J, Fan, Y-H, Xu, X, Zhang, H, Dou, J, Tang, Y, Zhong, X, Rojas, Y, Yu, Y, Zhao, Y, Vasudevan, S A, Nuchtern, J G, Kim, E S, Chen, X, Lu, F, Yang, J
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944268/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944268/

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