Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI

Antisocial Personality Disorder (APD) is a personality disorder that is most commonly associated with the legal and criminal justice systems. The study of the brain in APD has important implications in legal contexts and in helping ensure social stability. However, the neural contribution to the hig...

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Main Authors:	Liu, Huasheng, Liao, Jian, Jiang, Weixiong, Wang, Wei
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943846/

id	pubmed-3943846
recordtype	oai_dc
spelling	pubmed-39438462014-03-10 Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI Liu, Huasheng Liao, Jian Jiang, Weixiong Wang, Wei Research Article Antisocial Personality Disorder (APD) is a personality disorder that is most commonly associated with the legal and criminal justice systems. The study of the brain in APD has important implications in legal contexts and in helping ensure social stability. However, the neural contribution to the high prevalence of APD is still unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) to investigate the underlying neural mechanisms of APD. Thirty-two healthy individuals and thirty-five patients with APD were recruited. The amplitude of low-frequency fluctuations (ALFF) was analyzed for the whole brain of all subjects. Our results showed that APD patients had a significant reduction in the ALFF in the right orbitofrontal cortex, the left temporal pole, the right inferior temporal gyrus, and the left cerebellum posterior lobe compared to normal controls. We observed that the right orbitofrontal cortex had a negative correlation between ALFF values and MMPI psychopathic deviate scores. Alterations in ALFF in these specific brain regions suggest that APD patients may be associated with abnormal activities in the fronto-temporal network. We propose that our results may contribute in a clinical and forensic context to a better understanding of APD. Public Library of Science 2014-03-05 /pmc/articles/PMC3943846/ /pubmed/24598769 http://dx.doi.org/10.1371/journal.pone.0089790 Text en © 2014 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Liu, Huasheng Liao, Jian Jiang, Weixiong Wang, Wei
spellingShingle	Liu, Huasheng Liao, Jian Jiang, Weixiong Wang, Wei Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI
author_facet	Liu, Huasheng Liao, Jian Jiang, Weixiong Wang, Wei
author_sort	Liu, Huasheng
title	Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI
title_short	Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI
title_full	Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI
title_fullStr	Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI
title_full_unstemmed	Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI
title_sort	changes in low-frequency fluctuations in patients with antisocial personality disorder revealed by resting-state functional mri
description	Antisocial Personality Disorder (APD) is a personality disorder that is most commonly associated with the legal and criminal justice systems. The study of the brain in APD has important implications in legal contexts and in helping ensure social stability. However, the neural contribution to the high prevalence of APD is still unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) to investigate the underlying neural mechanisms of APD. Thirty-two healthy individuals and thirty-five patients with APD were recruited. The amplitude of low-frequency fluctuations (ALFF) was analyzed for the whole brain of all subjects. Our results showed that APD patients had a significant reduction in the ALFF in the right orbitofrontal cortex, the left temporal pole, the right inferior temporal gyrus, and the left cerebellum posterior lobe compared to normal controls. We observed that the right orbitofrontal cortex had a negative correlation between ALFF values and MMPI psychopathic deviate scores. Alterations in ALFF in these specific brain regions suggest that APD patients may be associated with abnormal activities in the fronto-temporal network. We propose that our results may contribute in a clinical and forensic context to a better understanding of APD.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943846/
_version_	1612064829320724480

Changes in Low-Frequency Fluctuations in Patients with Antisocial Personality Disorder Revealed by Resting-State Functional MRI

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