Transferrin-Conjugated SNALPs Encapsulating 2′-O-Methylated miR-34a for the Treatment of Multiple Myeloma

Transferrin-Conjugated SNALPs Encapsulating 2′-O-Methylated miR-34a for the Treatment of Multiple Myeloma

Stable nucleic acid lipid vesicles (SNALPs) encapsulating miR-34a to treat multiple myeloma (MM) were developed. Wild type or completely 2′-O-methylated (OMet) MiR-34a was used in this study. Moreover, SNALPs were conjugated with transferrin (Tf) in order to target MM cells overexpressing transferri...

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Bibliographic Details
Main Authors: Scognamiglio, Immacolata, Di Martino, Maria Teresa, Campani, Virginia, Virgilio, Antonella, Galeone, Aldo, Gullà, Annamaria, Gallo Cantafio, Maria Eugenia, Misso, Gabriella, Tagliaferri, Pierosandro, Tassone, Pierfrancesco, Caraglia, Michele, De Rosa, Giuseppe
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943297/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943297/

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