Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia

Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia

Two new flavonol glucuronides, quercetin 3-O-β-D-2″-acetylglucuronide (1) and quercetin 3-O-β-D-2″-acetylglucuronide methyl ester (2), along with four known flavonoids (3-6) were isolated from the whole parts of Rotala rotundifolia. The structures of 1 and 2 were elucidated by application of various...

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Main Authors: Zhang, Li-Jie, Yeh, Sheau-Farn, Yu, Ya-Ten, Kuo, Li-Ming Yang, Kuo, Yao-Haur
Format: Online
Language:English
Published: Medknow Publications & Media Pvt Ltd 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943002/
id pubmed-3943002
recordtype oai_dc
spelling pubmed-39430022014-04-08 Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia Zhang, Li-Jie Yeh, Sheau-Farn Yu, Ya-Ten Kuo, Li-Ming Yang Kuo, Yao-Haur Original Article Two new flavonol glucuronides, quercetin 3-O-β-D-2″-acetylglucuronide (1) and quercetin 3-O-β-D-2″-acetylglucuronide methyl ester (2), along with four known flavonoids (3-6) were isolated from the whole parts of Rotala rotundifolia. The structures of 1 and 2 were elucidated by application of various spectroscopic methods, including 1D and 2D NMR techniques. Biological evaluation showed that all of isolated flavonoid compounds have potent anti-oxidative activities by DPPH and superoxide anion methods, and kaempferol (3) and quercetin (4) exhibited significant anti-HBV activity assayed by anti-HBsAg production. The HPLC fingerprint with photodiode array detection (HPLC-DAD) for quality control of R. rotundifolia partitioned EtOAc layer was also established. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3943002/ /pubmed/24716106 Text en Copyright: © Journal of Traditional and Complementary Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Zhang, Li-Jie
Yeh, Sheau-Farn
Yu, Ya-Ten
Kuo, Li-Ming Yang
Kuo, Yao-Haur
spellingShingle Zhang, Li-Jie
Yeh, Sheau-Farn
Yu, Ya-Ten
Kuo, Li-Ming Yang
Kuo, Yao-Haur
Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
author_facet Zhang, Li-Jie
Yeh, Sheau-Farn
Yu, Ya-Ten
Kuo, Li-Ming Yang
Kuo, Yao-Haur
author_sort Zhang, Li-Jie
title Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
title_short Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
title_full Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
title_fullStr Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
title_full_unstemmed Antioxidative Flavonol Glucuronides and Anti-HBsAg Flavonol from Rotala rotundifolia
title_sort antioxidative flavonol glucuronides and anti-hbsag flavonol from rotala rotundifolia
description Two new flavonol glucuronides, quercetin 3-O-β-D-2″-acetylglucuronide (1) and quercetin 3-O-β-D-2″-acetylglucuronide methyl ester (2), along with four known flavonoids (3-6) were isolated from the whole parts of Rotala rotundifolia. The structures of 1 and 2 were elucidated by application of various spectroscopic methods, including 1D and 2D NMR techniques. Biological evaluation showed that all of isolated flavonoid compounds have potent anti-oxidative activities by DPPH and superoxide anion methods, and kaempferol (3) and quercetin (4) exhibited significant anti-HBV activity assayed by anti-HBsAg production. The HPLC fingerprint with photodiode array detection (HPLC-DAD) for quality control of R. rotundifolia partitioned EtOAc layer was also established.
publisher Medknow Publications & Media Pvt Ltd
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943002/
_version_ 1612064557151289344

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