Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells

Humane use of preclinical large animal cancer models plays a critical role in understanding cancer biology and developing therapeutic treatments. Among the large animal candidates, goats have great potentials as sustainable sources for large animal cancer model development. Goats are easier to handl...

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Bibliographic Details
Main Authors: Gong, Jianhua, Wang, Zhongde, Polejaeva, Irina, Salgia, Ravi, Kao, Chien-Min, Chen, Chin-Tu, Chen, Guangchun, Chen, Liaohai
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942380/