HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive immunity. Many TNFSF ligands require aggregation beyo...

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Bibliographic Details
Main Authors: Kanagavelu, Saravana, Termini, James M., Gupta, Sachin, Raffa, Francesca N., Fuller, Katherine A., Rivas, Yaelis, Philip, Sakhi, Kornbluth, Richard S., Stone, Geoffrey W.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938597/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938597/

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