STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells

STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells

Kaposis's sarcoma associated herpesvirus (KSHV) has been reported to infect, among others, monocytes and dendritic cells DCs impairing their function. However, the underlying mechanisms remain not completely elucidated yet. Here we show that DC exposure to active or UV-inactivated KSHV resulted...

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Main Authors: Santarelli, Roberta, Gonnella, Roberta, Di Giovenale, Giulia, Cuomo, Laura, Capobianchi, Angela, Granato, Marisa, Gentile, Giuseppe, Faggioni, Alberto, Cirone, Mara
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937791/
id pubmed-3937791
recordtype oai_dc
spelling pubmed-39377912014-03-04 STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells Santarelli, Roberta Gonnella, Roberta Di Giovenale, Giulia Cuomo, Laura Capobianchi, Angela Granato, Marisa Gentile, Giuseppe Faggioni, Alberto Cirone, Mara Article Kaposis's sarcoma associated herpesvirus (KSHV) has been reported to infect, among others, monocytes and dendritic cells DCs impairing their function. However, the underlying mechanisms remain not completely elucidated yet. Here we show that DC exposure to active or UV-inactivated KSHV resulted in STAT3 phosphorylation. This effect, partially dependent on KSHV-engagement of DC-SIGN, induced a high release of IL-10, IL-6 and IL-23, cytokines that in turn might maintain STAT3 in a phosphorylated state. STAT3 activation also correlated with a block of autophagy in DCs, as indicated by LC3II reduction and p62 accumulation. The IL-10, IL-6 and IL-23 release and the autophagic block could be overcome by inhibiting STAT3 activation, highlighting the role of STAT3 in mediating such effects. In conclusion, here we show that STAT3 activation can be one of the molecular mechanisms leading to KSHV-mediated DC dysfunction, that might allow viral persistence and the onset of KSHV-associated malignancies. Nature Publishing Group 2014-02-28 /pmc/articles/PMC3937791/ /pubmed/24577500 http://dx.doi.org/10.1038/srep04241 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Santarelli, Roberta
Gonnella, Roberta
Di Giovenale, Giulia
Cuomo, Laura
Capobianchi, Angela
Granato, Marisa
Gentile, Giuseppe
Faggioni, Alberto
Cirone, Mara
spellingShingle Santarelli, Roberta
Gonnella, Roberta
Di Giovenale, Giulia
Cuomo, Laura
Capobianchi, Angela
Granato, Marisa
Gentile, Giuseppe
Faggioni, Alberto
Cirone, Mara
STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
author_facet Santarelli, Roberta
Gonnella, Roberta
Di Giovenale, Giulia
Cuomo, Laura
Capobianchi, Angela
Granato, Marisa
Gentile, Giuseppe
Faggioni, Alberto
Cirone, Mara
author_sort Santarelli, Roberta
title STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
title_short STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
title_full STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
title_fullStr STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
title_full_unstemmed STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells
title_sort stat3 activation by kshv correlates with il-10, il-6 and il-23 release and an autophagic block in dendritic cells
description Kaposis's sarcoma associated herpesvirus (KSHV) has been reported to infect, among others, monocytes and dendritic cells DCs impairing their function. However, the underlying mechanisms remain not completely elucidated yet. Here we show that DC exposure to active or UV-inactivated KSHV resulted in STAT3 phosphorylation. This effect, partially dependent on KSHV-engagement of DC-SIGN, induced a high release of IL-10, IL-6 and IL-23, cytokines that in turn might maintain STAT3 in a phosphorylated state. STAT3 activation also correlated with a block of autophagy in DCs, as indicated by LC3II reduction and p62 accumulation. The IL-10, IL-6 and IL-23 release and the autophagic block could be overcome by inhibiting STAT3 activation, highlighting the role of STAT3 in mediating such effects. In conclusion, here we show that STAT3 activation can be one of the molecular mechanisms leading to KSHV-mediated DC dysfunction, that might allow viral persistence and the onset of KSHV-associated malignancies.
publisher Nature Publishing Group
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937791/
_version_ 1612062955569938432

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