High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years
Background: Recent studies investigating the use of optical coherence tomography (OCT) in multiple sclerosis (MS) patients have resulted in wide-ranging and often contradictory outcomes. This is mainly due to the complex etiology and heterogeneity of MS, physiological variations in the retinal nerve...
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Frontiers Media S.A.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932446/ |
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pubmed-39324462014-03-06 High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years Serbecic, Nermin Aboul-Enein, Fahmy Beutelspacher, Sven C. Khan, Adnan Vass, Clemens Kristoferitsch, Wolfgang Reitner, Andreas Schmidt-Erfurth, Ursula Neuroscience Background: Recent studies investigating the use of optical coherence tomography (OCT) in multiple sclerosis (MS) patients have resulted in wide-ranging and often contradictory outcomes. This is mainly due to the complex etiology and heterogeneity of MS, physiological variations in the retinal nerve fiber layer (RNFL) and/or total macular volume (TMV), and limitations in methodology. It remains to be discovered whether any retinal changes in MS develop continuously or in a stepwise fashion, and whether these changes occur in all or a subset of patients. High-resolution spectral domain-OCT devices (SD-OCT) would be required to detect subtle retinal changes and longitudinal studies would have to be carried out to investigate retinal changes over time. In addition, if the hypothesis is correct, then retinal and global brain tissue changes should be detected in a substantial majority of MS patients and detection should be possible with a high degree of disease activity and/or long disease course. Frontiers Media S.A. 2014-02-24 /pmc/articles/PMC3932446/ /pubmed/24605107 http://dx.doi.org/10.3389/fneur.2014.00020 Text en Copyright © 2014 Serbecic, Aboul-Enein, Beutelspacher, Khan, Vass, Kristoferitsch, Reitner and Schmidt-Erfurth. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Serbecic, Nermin Aboul-Enein, Fahmy Beutelspacher, Sven C. Khan, Adnan Vass, Clemens Kristoferitsch, Wolfgang Reitner, Andreas Schmidt-Erfurth, Ursula |
| spellingShingle |
Serbecic, Nermin Aboul-Enein, Fahmy Beutelspacher, Sven C. Khan, Adnan Vass, Clemens Kristoferitsch, Wolfgang Reitner, Andreas Schmidt-Erfurth, Ursula High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years |
| author_facet |
Serbecic, Nermin Aboul-Enein, Fahmy Beutelspacher, Sven C. Khan, Adnan Vass, Clemens Kristoferitsch, Wolfgang Reitner, Andreas Schmidt-Erfurth, Ursula |
| author_sort |
Serbecic, Nermin |
| title |
High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years |
| title_short |
High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years |
| title_full |
High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years |
| title_fullStr |
High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years |
| title_full_unstemmed |
High-Resolution Spectral Domain-Optical Coherence Tomography in Multiple Sclerosis, Part II – the Total Macular Volume. The First Follow-Up Study over 2 Years |
| title_sort |
high-resolution spectral domain-optical coherence tomography in multiple sclerosis, part ii – the total macular volume. the first follow-up study over 2 years |
| description |
Background: Recent studies investigating the use of optical coherence tomography (OCT) in multiple sclerosis (MS) patients have resulted in wide-ranging and often contradictory outcomes. This is mainly due to the complex etiology and heterogeneity of MS, physiological variations in the retinal nerve fiber layer (RNFL) and/or total macular volume (TMV), and limitations in methodology. It remains to be discovered whether any retinal changes in MS develop continuously or in a stepwise fashion, and whether these changes occur in all or a subset of patients. High-resolution spectral domain-OCT devices (SD-OCT) would be required to detect subtle retinal changes and longitudinal studies would have to be carried out to investigate retinal changes over time. In addition, if the hypothesis is correct, then retinal and global brain tissue changes should be detected in a substantial majority of MS patients and detection should be possible with a high degree of disease activity and/or long disease course. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932446/ |
| _version_ |
1612061091770138624 |