The Antidepressant Trans-2-Phenylcyclopropylamine Protects Mice from High-Fat-Diet-Induced Obesity

Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. Contrary to a recent report that inhibition of lysine-specific demethylase-1 by 2-PCPA results in increased...

Full description

Bibliographic Details
Main Authors: Shemesh, Adi, Abdulla, Arian, Yang, Fajun, Chua, Streamson C., Pessin, Jeffrey E., Zong, Haihong
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931726/