Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer

Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer

Leptomeningeal carcinomatosis is an infrequent disease and although its treatment is palliative, earlier diagnosis will lead to prolonged survival and improve functional outcome. Whole-body FDG-PET allows the entire spinal cord to be examined noninvasively, so close attention should be paid to the s...

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Main Authors: Grande, Maria Luz Dominguez, Rayo, Juan Ignacio, Serrano, Justo, Infante, Jose Rafael, Garcia, Lucia, Duran, Carmen, Gomez-Caminero, Felipe
Format: Online
Language:English
Published: Medknow Publications & Media Pvt Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928755/
id pubmed-3928755
recordtype oai_dc
spelling pubmed-39287552014-03-03 Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer Grande, Maria Luz Dominguez Rayo, Juan Ignacio Serrano, Justo Infante, Jose Rafael Garcia, Lucia Duran, Carmen Gomez-Caminero, Felipe Interesting Images Leptomeningeal carcinomatosis is an infrequent disease and although its treatment is palliative, earlier diagnosis will lead to prolonged survival and improve functional outcome. Whole-body FDG-PET allows the entire spinal cord to be examined noninvasively, so close attention should be paid to the spinal canal, since these lesions can easily be mistaken for physiologic uptake, sometimes there is no clinical suspicion and may occur without concurrent active cancer. We present a female patient with a history of carcinoma of the breast, who presented an elevation of serum tumor marker CA 15-3. An FDG-PET/CT study only revealed multiple abnormal uptake at the vertebral foramen at thoracic and lumbosacral regions suggesting leptomeningeal metastases that were confirmed by MRI and cerebrospinal fluid cytology. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3928755/ /pubmed/24591787 http://dx.doi.org/10.4103/0972-3919.125779 Text en Copyright: © Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Grande, Maria Luz Dominguez
Rayo, Juan Ignacio
Serrano, Justo
Infante, Jose Rafael
Garcia, Lucia
Duran, Carmen
Gomez-Caminero, Felipe
spellingShingle Grande, Maria Luz Dominguez
Rayo, Juan Ignacio
Serrano, Justo
Infante, Jose Rafael
Garcia, Lucia
Duran, Carmen
Gomez-Caminero, Felipe
Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer
author_facet Grande, Maria Luz Dominguez
Rayo, Juan Ignacio
Serrano, Justo
Infante, Jose Rafael
Garcia, Lucia
Duran, Carmen
Gomez-Caminero, Felipe
author_sort Grande, Maria Luz Dominguez
title Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer
title_short Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer
title_full Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer
title_fullStr Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer
title_full_unstemmed Leptomeningeal carcinomatosis as only pathological finding at FDG-PET/CT in case of tumor marker elevation in breast cancer
title_sort leptomeningeal carcinomatosis as only pathological finding at fdg-pet/ct in case of tumor marker elevation in breast cancer
description Leptomeningeal carcinomatosis is an infrequent disease and although its treatment is palliative, earlier diagnosis will lead to prolonged survival and improve functional outcome. Whole-body FDG-PET allows the entire spinal cord to be examined noninvasively, so close attention should be paid to the spinal canal, since these lesions can easily be mistaken for physiologic uptake, sometimes there is no clinical suspicion and may occur without concurrent active cancer. We present a female patient with a history of carcinoma of the breast, who presented an elevation of serum tumor marker CA 15-3. An FDG-PET/CT study only revealed multiple abnormal uptake at the vertebral foramen at thoracic and lumbosacral regions suggesting leptomeningeal metastases that were confirmed by MRI and cerebrospinal fluid cytology.
publisher Medknow Publications & Media Pvt Ltd
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928755/
_version_ 1612059886923808768

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