Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia

Community-acquired pneumonia (CAP) is a major cause of morbidity in children. This study estimated the proportion of children with pneumococcal CAP among children hospitalised with CAP in Belgium and describes the causative serotype distribution after implementation of the 7-valent pneumococcal conj...

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Main Authors:	De Schutter, Iris, Vergison, Anne, Tuerlinckx, David, Raes, Marc, Smet, Julie, Smeesters, Pierre R., Verhaegen, Jan, Mascart, Françoise, Surmont, Filip, Malfroot, Anne
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928328/

id	pubmed-3928328
recordtype	oai_dc
spelling	pubmed-39283282014-02-20 Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia De Schutter, Iris Vergison, Anne Tuerlinckx, David Raes, Marc Smet, Julie Smeesters, Pierre R. Verhaegen, Jan Mascart, Françoise Surmont, Filip Malfroot, Anne Research Article Community-acquired pneumonia (CAP) is a major cause of morbidity in children. This study estimated the proportion of children with pneumococcal CAP among children hospitalised with CAP in Belgium and describes the causative serotype distribution after implementation of the 7-valent pneumococcal conjugate vaccine. Children 0–14 years hospitalised with X-ray-confirmed CAP were prospectively enrolled in a multicentre observational study. Acute and convalescent blood samples were collected. Pneumococcal aetiology was assessed by conventional methods (blood or pleural fluid cultures with Quellung reaction capsular typing or polymerase chain reaction [PCR] in pleural fluid), and recently developed methods (real-time PCR in blood and World Health Organization-validated serotype-specific serology). A total of 561 children were enrolled. Pneumococcal aetiology was assessed by conventional methods in 539, serology in 171, and real-time PCR in blood in 154. Pneumococcal aetiology was identified in 12.2% (66/539) of the children by conventional methods alone but in 73.9% by the combination of conventional and recently developed methods. The pneumococcal detection rate adjusted for the whole study population was 61.7%. Serotypes 1 (42.3%), 5 (16.0%), and 7F(7A) (12.8%) were predominant. In conclusion, Streptococcus pneumoniae remains the predominant bacteria in children hospitalised for CAP in Belgium after implementation of 7-valent pneumococcal conjugate vaccine, with non-vaccine-serotypes accounting for the majority of cases. The use of recently developed methods improves diagnosis of pneumococcal aetiology. Public Library of Science 2014-02-18 /pmc/articles/PMC3928328/ /pubmed/24558464 http://dx.doi.org/10.1371/journal.pone.0089013 Text en © 2014 De Schutter et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	De Schutter, Iris Vergison, Anne Tuerlinckx, David Raes, Marc Smet, Julie Smeesters, Pierre R. Verhaegen, Jan Mascart, Françoise Surmont, Filip Malfroot, Anne
spellingShingle	De Schutter, Iris Vergison, Anne Tuerlinckx, David Raes, Marc Smet, Julie Smeesters, Pierre R. Verhaegen, Jan Mascart, Françoise Surmont, Filip Malfroot, Anne Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia
author_facet	De Schutter, Iris Vergison, Anne Tuerlinckx, David Raes, Marc Smet, Julie Smeesters, Pierre R. Verhaegen, Jan Mascart, Françoise Surmont, Filip Malfroot, Anne
author_sort	De Schutter, Iris
title	Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia
title_short	Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia
title_full	Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia
title_fullStr	Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia
title_full_unstemmed	Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia
title_sort	pneumococcal aetiology and serotype distribution in paediatric community-acquired pneumonia
description	Community-acquired pneumonia (CAP) is a major cause of morbidity in children. This study estimated the proportion of children with pneumococcal CAP among children hospitalised with CAP in Belgium and describes the causative serotype distribution after implementation of the 7-valent pneumococcal conjugate vaccine. Children 0–14 years hospitalised with X-ray-confirmed CAP were prospectively enrolled in a multicentre observational study. Acute and convalescent blood samples were collected. Pneumococcal aetiology was assessed by conventional methods (blood or pleural fluid cultures with Quellung reaction capsular typing or polymerase chain reaction [PCR] in pleural fluid), and recently developed methods (real-time PCR in blood and World Health Organization-validated serotype-specific serology). A total of 561 children were enrolled. Pneumococcal aetiology was assessed by conventional methods in 539, serology in 171, and real-time PCR in blood in 154. Pneumococcal aetiology was identified in 12.2% (66/539) of the children by conventional methods alone but in 73.9% by the combination of conventional and recently developed methods. The pneumococcal detection rate adjusted for the whole study population was 61.7%. Serotypes 1 (42.3%), 5 (16.0%), and 7F(7A) (12.8%) were predominant. In conclusion, Streptococcus pneumoniae remains the predominant bacteria in children hospitalised for CAP in Belgium after implementation of 7-valent pneumococcal conjugate vaccine, with non-vaccine-serotypes accounting for the majority of cases. The use of recently developed methods improves diagnosis of pneumococcal aetiology.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928328/
_version_	1612059722823761920

Pneumococcal Aetiology and Serotype Distribution in Paediatric Community-Acquired Pneumonia

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